-Risk-stratify patients with acute pulmonary embolism using clinical, laboratory, and imaging findings to identify patients at low, intermediate, and high risk for deterioration.

-Select appropriate initial therapy for acute PE, including anticoagulation, thrombolysis, catheter-directed therapy, and surgical embolectomy based on hemodynamic status and bleeding risk.

-Develop an evidence-based approach to the first 24 hours of PE management, including anticoagulant selection, monitoring, management of hemodynamic instability, and indications for escalation of therapy.